Clinical Cancer Genomic Medicine

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  • ISBN: 9780443153211
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Clinical Cancer Genomic Medicine: Translational and Applied

covers all major aspects of genetics and genomic of cancer development, diagnosis, and management and the use of them in the clinical setting.

It aims to provide readers with not only the genetic basis of cancer, but the role genomics play in understanding the molecular basis of the disease along with aiding diagnosis and treatment.

The content is split into three parts: the first, Fundamentals of Cancer Genetics and Genomics, discusses the basics of oncogenomic and emerging technologies; the second, Clinical Cancer Genetics and Genomics, brings information on specific cancer types, such as breast, gastrointestinal, ocular, skin and pediatric; and the third, Clinical Cancer Genomic Medicine, encompasses knowledge on diagnostic cancer genomic techniques, surgical approaches, and ethical, legal, and social implications of cancer genomic testing.

It is a valuable resource for oncologists, clinicians, researchers, healthcare workers and members of biomedical field who needs to understand more about the benefits of genetics and genomics for cancer and their application in clinical setting.

Section I: Fundamentals of Cancer genetics and genomics

1. The human genome- organisation & function

2. Introduction to cancer genetics

3. Oncogenes and tumour suppressor genes

4. Cancer epigenomics

5. Cancer and the microbiome- the Oncobiome

6. Cancer immunogenomics

7. Cancer pharmacogenomics

8. Genomic Technologies for Tumour Profiling

9. New emerging technologies- The liquid biopsy

10. Gene and genome editing

11. Bioinformatics for Cancer Genome Analysis

Section II: Clinical cancer genetics and genomics

12. Classification and epidemiology of the genetic and inherited cancer – hereditary cancer family syndromes

13. Breast and ovarian cancer including endometrial cancer

14. Gastrointestinal malignancies – oesophagus, colo-rectal, hepato-biliary and pancreatic

15. Central nervous system tumours

16. Neoplasia of endocrine system (solitary and multiple)

17. Ocular tumours – retinoblastoma

18. Hematological cancer and lympho-reticular malignancy

19. Oro-pharyngeal and lung cancers

20. Malignant melanoma and related skin neoplasia

21. Childhood tumours and paediatric malignant neoplasia disorders

22. Malformation syndromes with neoplasia

Section III: Clinical cancer genomic medicine

23. Integration of cancer genomics in clinical medicine

24. Cancer genetic counselling

25. Diagnostic cancer genomic laboratory – organization & function / cancer database

26. Targeted therapy and screening in cancer genomic / precision medicine

27. Surgical approaches in clinical cancer genetics and genomics

28. Ethical, legal and social implications of cancer genomic testing

29. The future of cancer in the context of the genomics era

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