More than 50 years have passed since the use of L-dopa in the palliative treatment of Parkinsonâs disease, but it remains the most common treatment despite inducing severe side effects such as dyskinesia after 4â6 years of use.
Numerous preclinical investigations based on endogenous neurotoxin models have promised various therapies for Parkinsonâs disease, but these efforts have failedãwhen attempting to transfer these successful results to preclinical studies.
Although several publications have warned of these failures, the scientific community remains mostly unaware, and there is a need to focus their efforts on potential therapeutics that can slow or halt development of the disease.
Clinical Studies and Therapies in Parkinsonâs Disease: Translations from Preclinical Models analyzes preclinical models based on exogenous neurotoxins and why they have failed.
Neuroscientists, neurologists, and neuropharmacologists will benefit greatly from the bookâs discussion of these newer models, their benefits, and the need for their implementation.
This book also provides the basic concepts of dopamine metabolism for students taking courses in neurochemistry, neuroscience, neuropharmacology, biochemistry, and medicine.
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