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Thoroughly updated to reflect today's recent advances in adult and pediatric endocrinology, DeGrootâs Endocrinology, 8th Edition, remains the comprehensive, international reference of choice for todayâs endocrinologists and fellows.
A full peer review of the previous edition, conducted by a largely new group of renowned editors, was used to update this trusted, two-volume resource.
In-depth coverage of both basic and clinical aspects of endocrinology and up-to-date information on the treatment and management of endocrine disorders are provided by a diverse group of expert contributors from six continents.
A full-color format and helpful algorithms summarize clinical decision-making and practical approaches to patient management.
Organizes content by all the glands that regulate the endocrine system while integrating basic science and clinical presentations of disease.
Includes new chapters: Anatomy and Physiology of the Hypothalmus and Pituitary, Differentiated Thyroid Cancer, Medullary Thyroid Cancer, Drugs that Affect Thyroid Function, Genetic Disorders of the Adrenal Cortex, Adrenal Pathology, Primary Aldosteronism, Transgender Healthcare, Erectile Dysfunction, Prevalence and Causes of Male Infertility, Sexual Dysfunction in the Female, Glucose Toxicity and Oxidative Stress.
Emphasizes basic science and evidence-based practice throughout.
Features extensive updates to content on thyroid and adrenal disfunction, endocrine-disrupting chemicals and human disease, clinical management of diabetes, and advances in genetics.
Includes algorithms to outline effective treatment protocols.
Contains new emphasis boxes that highlight key points in each chapter.
Enhanced eBook version included with purchase.
Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
1Â Principles of Endocrinology
2Â Regulation of Islet Hormone Synthesis and Secretion
2Â Principles of Endocrine Measurements
3Â Applications of Genetics in Endocrinology
3Â Endocrine-Disrupting Chemicals and Human Disease
3Â Endocrine Rhythms, the Sleep-Wake Cycle, and Biological Clocks
4Â Prolactinomas and Disorders of Prolactin Secretion
5Â Hypopituitarism including Growth Hormone Deficiency
6Â Acromegaly
7Â Development of the Pituitary
7Â Cushing's Disease
8Â CLINICALLY NONFUNCTIONING SELLAR MASSES
9Â TSH-Producing Pituitary Tumors
10Â Pituitary Surgery
11Â CRANIOPHARYNGIOMAS AND PARASELLAR MASSES
12Â DISORDERS OF SODIUM, DIABETES INSIPIDUS AND HYPONATRAEMIA
13Â Anatomy and Physiology of the Hypothalmus and Pituitary
14Â Genetic Disorders of the Pituitary
15Â Aggressive Pituitary Tumors
16Â Radiotherapy in Pituitary Tumors
17Â Somatic Growth and Maturation: Growth hormone and Other Growth Factors
18Â Growth Hormone Deficiency in Children
19Â Basic and Clinical Aspects of Appetite Regulation and Energy Expenditure
20Â Obesity: Risk, Risk Factors, and Medical Management
21Â GENETIC OBESITY SYNDROMES
22Â Regulation of Intermediary Metabolism During Fasting, Feeding, and Exercise
23Â Adipose Tissue Function: Metabolic and Endocrine
24Â Lipodystrpohy Syndromes
25Â Lipoprotein Metabolism and the Treatment of Lipid Disorders
26Â Metabolic Syndrome
27Â Bariatric Procedures and Operations
28Â Development of the Endocrine Pancreas
29Â Regulation of Islet Hormone Synthesis and Secretion
30Â Mechanisms of Insulin Action
31Â Classification and Diagnosis of Diabetes Mellitus
32Â Autoimmune (Type 1)Diabetes Mellitus: Etiology, Pathogenesis, Prediction, and Prevention
33Â Type 2 Diabetes Mellitus: Etiology, Pathogenesis, and Natural History
34Â Diabetes Mellitus and Pregnancy
35Â Hyperglycemia Secondary to Non-Traditional Diabetic Conditions and Therapies
36Â Beta-cell Glucose Toxicity and Oxidative Stress
37Â DIABETIC KETOACIDOSIS AND HYPERGLYCEMIC HYPEROSMOLAR STATE
38Â Hypoglycemia and Hypoglycemic Syndromes
39Â Treatment of Type 1 Diabetes Mellitus in Adults
40Â Clinical Management of Type 2 Diabetes Mellitus
41Â Pancreas and Islet Transplantation
42Â Diabetes and Long-Term Complications
43Â Diabetic Eye Disease
44Â Diabetic Neuropathy
45Â Glucose Sensors and Insulin Pumps
45Â Diabetic Kidney Disease
46Â Diabetic Foot and Vascular Complications
47Â Parathyroid Hormone and the Parathyroid Hormone Receptor Type 1 in the Regulation of Calcium and Phosphate Homeostasis and Bone Metabolism
48Â Parathyroid Hormone-Related Protein
49Â Calcitonin
50Â Vitamin D: From Photosynthesis, Metabolism, and Action to Clinical Applications
51Â Bone Development and Remodeling
52Â Regulation of Calcium Homeostasis and Genetic Disorders that Affect Calcium Metabolism
53Â Genetic Disorders of Phosphate Homeostasis
54Â Primary Hyperparathyroidism
55Â Hypercalcemia of Malignancy
56Â Surgical Management of Hyperparathyroidism
57 PSEUDOHYPOPARATHYROIDISM, ALBRIGHTâS HEREDITARY OSTEODYSTROPHY, AND PROGRESSIVE OSSEOUS HETEROPLASIA: DISORDERS CAUSED BY GNAS MUTATIONS THAT REDUCE Gsα ACTIVITY
58Â Genetic Defects in Vitamin D Metabolism and Action
59Â Hereditary Disorders of the Skeleton
60Â Osteoporosis
61Â CKD-MBD Syndrome: Chronic Kidney Disease Produced Disorders in Skeletal, Vascular, and Cardiac Tissues and Mineral Metabolism
62Â Disorders of Mineralization
63Â Paget's Disease of Bone
64Â Anatomy and Development of the Thyroid
65Â Thyroid-Stimulating Hormone and TSH Receptor
66Â Thyroid Hormone Transporters and Metabolism
67Â Thyroid Hormone Action
68Â Thyroid Function Testing (TSH, T3, and T4)
69Â Thyroid Imaging
70Â Pathology of the Thyroid Gland
71Â Graves' Disease
72Â Gravesâ Orbitopathy
73Â Thyroiditis
74Â Hypothyroidism
75Â Thyroid and Pregnancy
76Â Iodine Nutrition and the Thyroid
77Â Euthyroid and hyperthyroid nodules and goiter
78Â Differentiated Thyroid Cancer â Streamlining Diagnosis And Optimizing Management
79Â Medullary Thyroid Cancer
80Â Anaplastic (Undifferentiated) Thyroid Carcinoma
81Â RESISTANCE TO THYROID HORMONE & GENETIC DEFECTS OF THE THYROID
82Â Surgical Management of Thyroid Disease
83Â Nonthyroidal Illness Syndrome
84Â Drugs that Affect Thyroid Function
85 Adrenal development and Homeostasis
86Â Genetic Disorders of the Adrenal Cortex
87Â The Principles, Enzymes, and Pathways of Human Steroidogenesis
88Â Mineralocorticoids: Physiology, metabolism, receptors and resistance
89Â Glucocorticoid Receptors: Mechanisms of Action in Health and Disease
90Â Adrenal Androgens Adrenarche and Adrenopause
91Â Adrenal Pathology
92Â Adrenal Gland Imaging
93Â Adrenal Insufficiency
94Â Defects of Adrenal Steroidogenesis
95Â Adrenal Genomics II: Familial and sporadic neoplasia
96Â Primary Aldosteronism
97Â Adrenal Cushingâs Syndrome
98Â Adrenocortical Carcinoma
99Â Pheochromocytoma
100Â Adrenal Surgery
101Â Hypothalamic Regulation of GnRH
101Â Differences of Sex Development
102Â Endocrinology of Sexual Maturation and Puberty
103Â Endocrinology of Pubertal Disorders
 TBD
104Â Transgender Health Care
105Â Gonadotropin regulation, Androgen and estrogen physiology
106Â Hypogonadism â Pathogenesis, Diagnosis and Treatment
107Â Testosterone Deficiency: Aging and Chronic Disease
108Â Gynecomastia
109Â Erectile dysfunction
110Â Misuse and Abuse of Anabolic Hormones
111Â Regulation of Spermatogenesis
112Â Clinical Management of Male Infertility
113Â Male Contraception
114Â Testicular Dysgenesis Syndrome and Testicular Tumors
115Â Prevalence and Causes of Male Infertility
116Â Benign Prostatic Hyperplasia and Prostate Cancer
117Â The Menstrual Cycle and Disorders of Ovulation
118Â Prostate Cancer
118Â Folliculogenesis, Ovulation, and Luteogenesis
119Â Ovarian Hormone Synthesis
120Â Estrogen and Progesterone Action
121Â Prostate BPH and Prostate Cancer
121Â Contraception
122Â Menopause and Perimenopause
123Â Female Infertility: Evaluation and Management
124Â Androgen Excess Disorders in Women
125Â ENDOMETRIOSIS
126Â Uterine Fibroids and Adenomyosis.
127Â Hormonal Control of Breast Development
128Â Sexual Dysfunction in the Female
129Â Hormonal Control of Human Pregnancy and Parturition
130Â Fetal and Neonatal Endocrinology
131Â Hormonal Changes and Pregnancy Testing
132Â Autoimmune Polyglandular Syndromes
133Â Multiple Endocrine Neoplasia Type 1
134Â Multiple Endocrine Neoplasia Types 2 and 3, and Medullary Thyroid Carcinoma
135Â Neuroendocrine Tumor Syndromes
136Â Ectopic Hormone Syndromes
137Â Endocrine-Disrupting Chemicals and Human Health
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